Honglin Chen Selected Research

Human Influenza (Influenza)

12/2023	An intranasal influenza virus-vectored vaccine prevents SARS-CoV-2 replication in respiratory tissues of mice and hamsters.
7/2022	A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2.
1/2022	Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models.
12/2021	Discovery of a Novel Specific Inhibitor Targeting Influenza A Virus Nucleoprotein with Pleiotropic Inhibitory Effects on Various Steps of the Viral Life Cycle.
8/2021	Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges.
1/2021	Establishment of a rapid ELISPOT assay for influenza virus titration and neutralizing antibody detection.
1/2021	Coinfection by Severe Acute Respiratory Syndrome Coronavirus 2 and Influenza A(H1N1)pdm09 Virus Enhances the Severity of Pneumonia in Golden Syrian Hamsters.
11/2020	PB1-F2 protein of highly pathogenic influenza A (H7N9) virus selectively suppresses RNA-induced NLRP3 inflammasome activation through inhibition of MAVS-NLRP3 interaction.
1/2020	Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus.
1/2019	Generation of DelNS1 Influenza Viruses: a Strategy for Optimizing Live Attenuated Influenza Vaccines.

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Honglin Chen Research Topics

Disease

55	Infections 12/2023 - 05/2008
39	Human Influenza (Influenza) 12/2023 - 06/2007
21	Influenza in Birds (Avian Flu) 01/2018 - 06/2006
20	Neoplasms (Cancer) 01/2024 - 04/2009
20	COVID-19 12/2023 - 01/2020
16	Virus Diseases (Viral Diseases) 01/2022 - 01/2005
13	Nasopharyngeal Carcinoma 08/2023 - 11/2002
9	Osteoporosis 05/2024 - 01/2015
9	Pneumonia (Pneumonitis) 01/2017 - 08/2010
8	Inflammation (Inflammations) 01/2022 - 01/2015
6	Hepatocellular Carcinoma (Hepatoma) 11/2023 - 06/2013
5	Epstein-Barr Virus Infections 11/2023 - 04/2003
4	Carcinoma (Carcinomatosis) 12/2020 - 12/2013
4	Neoplasm Metastasis (Metastasis) 05/2020 - 11/2018
3	Cognitive Dysfunction 05/2024 - 01/2021
3	Wounds and Injuries (Trauma) 10/2023 - 08/2008
3	Stomach Neoplasms (Stomach Cancer) 04/2023 - 02/2006
3	Liver Diseases (Liver Disease) 12/2022 - 12/2021
3	Weight Loss (Weight Reduction) 08/2021 - 12/2020
3	Coinfection 01/2021 - 03/2010
3	Viremia 12/2018 - 03/2010
2	Hypoxia (Hypoxemia) 01/2024 - 01/2022
2	Bone Diseases (Bone Disease) 10/2023 - 08/2021
2	Dementia (Dementias) 01/2023 - 01/2022
2	Musculoskeletal Diseases (Musculoskeletal Disease) 01/2022 - 01/2021
2	Fever (Fevers) 01/2022 - 06/2013
2	Bone Resorption 01/2022 - 08/2021
2	Body Weight (Weight, Body) 01/2022 - 12/2020
2	Reperfusion Injury 12/2017 - 01/2016
2	Severe Acute Respiratory Syndrome 10/2015 - 12/2013
2	Adenocarcinoma of Lung 03/2015 - 06/2013
2	Adenocarcinoma 06/2013 - 04/2009
1	Neuroinflammatory Diseases 01/2024
1	Edema (Dropsy) 01/2024

Drug/Important Bio-Agent (IBA)

29	VaccinesIBA 12/2023 - 09/2010
28	Proteins (Proteins, Gene)FDA Link 06/2023 - 01/2005
15	Antiviral Agents (Antivirals)IBA 12/2021 - 06/2010
14	CytokinesIBA 01/2022 - 03/2010
12	RNA (Ribonucleic Acid)IBA 05/2024 - 02/2009
11	Hemagglutinins (Hemagglutinin)IBA 01/2019 - 10/2009
9	Biomarkers (Surrogate Marker)IBA 05/2024 - 04/2009
8	NucleoproteinsIBA 12/2023 - 05/2009
8	ChemokinesIBA 01/2022 - 03/2010
8	AntigensIBA 01/2019 - 05/2009
7	Neutralizing AntibodiesIBA 01/2022 - 06/2012
7	Oseltamivir (Tamiflu)FDA Link 01/2019 - 12/2009
6	AntibodiesIBA 08/2023 - 06/2007
6	DNA (Deoxyribonucleic Acid)IBA 08/2023 - 06/2012
6	MicroRNAs (MicroRNA)IBA 05/2020 - 07/2013
6	Viral ProteinsIBA 01/2019 - 06/2009
5	Influenza Vaccines (Influenza Vaccine)FDA Link 08/2021 - 12/2016
5	Viral RNAIBA 01/2020 - 02/2009
5	Monoclonal AntibodiesIBA 10/2017 - 01/2009
4	Immunoglobulin G (IgG)IBA 01/2022 - 04/2016
4	Indicators and Reagents (Reagents)IBA 01/2022 - 01/2011
4	Broadly Neutralizing AntibodiesIBA 01/2021 - 10/2017
4	Neuraminidase (Sialidase)IBA 01/2017 - 06/2007
3	Therapeutic UsesIBA 10/2023 - 01/2015
3	Nucleocapsid ProteinsIBA 12/2020 - 05/2010
3	Interleukin-6 (Interleukin 6)IBA 03/2016 - 05/2012
3	EnzymesIBA 12/2015 - 11/2002
3	Peptides (Polypeptides)IBA 06/2009 - 02/2009
2	HydrogelsIBA 01/2024 - 07/2022
2	N-methyladenosineIBA 11/2023 - 01/2023
2	ProteomeIBA 09/2023 - 01/2021
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2023 - 10/2009
2	C-Reactive ProteinIBA 01/2023 - 01/2020
2	Circular RNAIBA 01/2023 - 01/2022
2	IntegrinsIBA 12/2022 - 01/2021
2	BNT162 VaccineIBA 01/2022 - 12/2021
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 01/2014
2	sinovac COVID-19 vaccineIBA 01/2022 - 12/2021
2	DNA VaccinesIBA 01/2022 - 06/2012
2	plastrum testudinisIBA 08/2021 - 08/2021
2	Topotecan (Hycamtin)FDA LinkGeneric 01/2021 - 12/2020
2	9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)IBA 01/2021 - 12/2020
2	Amino Acids FDA Link 12/2020 - 01/2016
2	ElementsIBA 01/2019 - 03/2016
2	MF59 oil emulsionIBA 11/2017 - 04/2016
2	EpitopesIBA 01/2017 - 01/2009
2	Interleukin-8 (Interleukin 8)IBA 03/2016 - 12/2013
2	Transforming Growth Factor beta (TGF-beta)IBA 03/2016 - 10/2010
2	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 03/2016 - 12/2013
2	ImmunosorbentsIBA 12/2015 - 11/2002
2	Messenger RNA (mRNA)IBA 10/2015 - 12/2013
2	Small Interfering RNA (siRNA)IBA 10/2015 - 01/2014
2	Pamidronate (Aredia)FDA LinkGeneric 01/2015 - 10/2014
2	Humanized Monoclonal AntibodiesIBA 04/2011 - 07/2010
2	AndrogensIBA 12/2010 - 01/2010
2	Gefitinib (Iressa)FDA Link 06/2010 - 04/2009
2	Immune Sera (Antisera)IBA 04/2009 - 01/2009
1	DisulfidesIBA 05/2024
1	baicalinIBA 04/2024
1	p38 Mitogen-Activated Protein KinasesIBA 04/2024
1	AQ4NIBA 01/2024

Therapy/Procedure

19	Therapeutics 01/2024 - 04/2009
5	Chinese Traditional Medicine (Traditional Chinese Medicine) 10/2023 - 01/2020
2	Aftercare (After-Treatment) 11/2023 - 02/2016
2	Activities of Daily Living (ADL) 01/2022 - 01/2021
1	Drug Therapy (Chemotherapy) 01/2024